Swastikas and slogans were spray-painted on about a dozen cars parked outside a mostly Jewish fraternity house at Penn State.
The graffiti, spray-painted early Friday morning, appeared to be directed at the Beta Sigma Beta house, State College Police told The Associated Press.
A garage and a dumpster also were vandalized.
In addition to anti-Semitic messages, the graffiti included crude sexual pictures and phrases, according to the Centre Daily Times.
“We are more worried about the message,” State College police Lt. Keith Robb told the paper. “The vandalism is bad enough, but we want to investigate a predominately Jewish frat (targeted) with that kind of message.”